Bag-in/Bag-Out Filter System | Zero-Leak Containment | ISO 14644 Pharma & Biosecurity

Bag-in/Bag-Out Filter System | Zero-Leak Containment | ISO 14644 Pharma & Biosecurity

The Bag-in/Bag-Out (BIBO) filter device is a specialized containment system designed for safely handling hazardous substances, such as toxic dusts, radioactive aerosols, or high-purity particles, where minimal operator exposure and zero leakage are critical. It enables the safe replacement of contaminated filters without direct contact between operators and hazardous materials. The system features a sealed, negative-pressure enclosure with replaceable inner and outer bags: when filter replacement is needed, the used filter is sealed within an internal bag, which is then enclosed by an external bag, ensuring contaminants remain trapped throughout the process. This design is pivotal in industries where exposure to harmful agents could pose severe health, environmental, or regulatory risks.

Key Features & Advantages

1. Absolute Containment

• Dual-Bag Sealing Mechanism: Inner and outer bags create a double-layer barrier, eliminating cross-contamination and leakage during filter installation/removal.
• Negative-Pressure Operation: Maintains a pressure differential to prevent hazardous air from escaping into the environment, even during bag replacement.

2. Operator Safety

• No Direct Contact: Filters are replaced through built-in gloves or ports, ensuring operators never touch contaminants.
• Compliance with Strict Safety Standards: Meets global regulations (e.g., OSHA, CE, ASME N510) for handling high-risk materials, reducing liability and workplace hazards.

3. High Efficiency Filtration

• HEPA/ULPA Compatibility: Supports filters with ≥99.995% (HEPA) or ≥99.9995% (ULPA) efficiency at 0.3μm, ideal for capturing ultra-fine particles.
• Customizable Filtration Stages: Can integrate pre-filters, activated carbon, or specialty media for multi-stage purification of gases, vapors, or particulates.

4. Flexibility & Adaptability

• Modular Design: Easily integrated into existing ventilation systems, fume hoods, or process equipment (e.g., mixers, dryers, kilns).
• Size Versatility: Available in compact bench-top units for lab use or large industrial systems for manufacturing lines.

5. Durability & Low Maintenance

• Chemical-Resistant Materials: Constructed from stainless steel, polypropylene, or other inert materials to withstand corrosive environments.
• Long Lifespan: Reduces downtime with robust components and simplified bag replacement, minimizing waste and operational costs.

Application Scenarios

1. Nuclear Industry

• Radioactive Aerosol Control: Used in nuclear power plants, reprocessing facilities, or waste storage sites to filter air containing radioactive particulates (e.g., uranium, plutonium dusts), ensuring compliance with IAEA and ASME N510 standards.
• Decontamination Systems: Integrates into glove boxes or hot cells to safely handle radioactive waste during maintenance or decommissioning.

2. Pharmaceutical & Biotechnology

• Aseptic Processing: Maintains sterile environments in drug manufacturing (e.g., API synthesis, vaccine production) by preventing cross-contamination between batches or with external contaminants.
• High-Potency Drugs: Safely handles cytotoxic compounds (e.g., oncology drugs) to protect operators from exposure during filtration and powder handling.

3. Chemical Manufacturing

• Toxic Dust Filtration: Captures harmful chemicals (e.g., lead, asbestos, or volatile organic compounds) in processes like milling, blending, or packaging, adhering to OSHA PELs (Permissible Exposure Limits) and EPA regulations.
• Explosive Environment Compliance: ATEX-certified models manage flammable dusts (e.g., aluminum, flour) in hazardous zones, reducing explosion risks.

4. Semiconductor & Electronics

• Ultra-Pure Air Filtration: Provides ULPA-grade filtration in cleanrooms (ISO Class 1–8) to remove nanoparticles, metallic contaminants, or molecular pollutants that could damage microchips or display panels.
• Chemical Vapor Deposition (CVD): Integrates into CVD chambers to filter corrosive gases (e.g., ammonia, silane) while preventing particle deposition on sensitive surfaces.

5. Research Laboratories & Hazmat Handling

• Biohazard Containment: Safely processes pathogens, allergens, or genetically modified materials in BSL-3/BSL-4 labs, meeting CDC and NIH biosafety guidelines.
• Emergency Response: Deployable in mobile units for rapid filtration during chemical spills, nuclear accidents, or airborne disease outbreaks.

6. Aerospace & Defense

• Military Decontamination: Cleans air in mobile shelters, aircraft, or tank interiors, removing chemical warfare agents (e.g., sarin, VX) or biological threats.
• Propellant Handling: Filters rocket fuel residues (e.g., hydrazine) in missile manufacturing facilities to protect workers from toxic fumes.

FAQ 1:
Q: Does this system prevent operator exposure during viral filter changes in BSL-3 labs?
A: Yes, triple-seal gaskets and negative pressure interlocks achieve 0.001% leakage (tested per NSF/ANSI 49).
FAQ 2:
Q: Can it handle 24"x24"x12" HEPA filters with rigid frames?
A: Adjustable clamp rails accommodate 20"-36" filter sizes, including rigid/pleated designs (max 50kg).
FAQ 3:
Q: How to decontaminate after handling Category 3/4 biohazards?
A: Integrated VHP ports enable in-situ sterilization cycles (validated for 6-log reduction).